CDK1 is a "normal" protein - its presence drives cells through the cycle of replication. And MHC Class I molecules are "normal" as well - they present bits of proteins on the surfaces of cells for examination by the immune system. But a University of Colorado Cancer Center study published in the journal Cancer Research shows that a population of cancer cells marked by MHC Class I molecules and high CDK1 is anything but normal. In fact, these MHC Class I-high, CDK1 high molecules may be at the heart of conditions including melanoma, pancreatic and colon cancers. These cells may, in fact, be the long-sought cancer stem cells that often resist treatments like chemotherapy to reseed these cancers once treatment ends. From the outset, the goal of this study was different than most. Often, cancer researchers will grow tumors and then ask what kinds of drugs or genetic changes make tumors grow or shrink. However, the current study wondered not what makes tumors change size, but what … [Read more...] about Cancer Stem Cells Use Normal Genes in Abnormal Ways
Stem cell traduction
Researchers at the Chinese Academy of Sciences were able to produce healthy mice with two mothers that went on to have normal offspring of their own. Mice from two dads were also born but only survived for a couple of days. The work, presented October 11 in the journal Cell Stem Cell, looks at what makes it so challenging for animals of the same sex to produce offspring and suggests that some of these barriers can be overcome using stem cells and targeted gene editing. "We were interested in the question of why mammals can only undergo sexual reproduction. We have made several findings in the past by combining reproduction and regeneration, so we tried to find out whether more normal mice with two female parents, or even mice with two male parents, could be produced using haploid embryonic stem cells with gene deletions," says co-senior author Qi Zhou. While some reptiles, amphibians, and fish can reproduce with one parent of the same sex, it's challenging for mammals to do the same … [Read more...] about Mouse Pups With Same-Sex Parents Born in China Using Stem Cells and Gene Editing
It's not the amount of fat, but the ability to store fat in the right locations, that equates to good metabolic health in humans. In part, for this to occur, new fat cells must be made "on demand" when the body has an energy surplus. John Bracht, American University biology assistant professor, and his students discovered a new type of cell state that could help ensure one always has the ability to generate healthy fat cells. The finding falls in line with increasing scientific discoveries elucidating how complex our cells are and how much we have yet to learn about their makeup. The discovery involves stem cells. Stem cells are usually thought of as replicating cells. Other cells perform specific functions. To turn into a specialized cell, a stem cell must be given instructions. As the team grew stem cells in the petri dish, they noticed some stem cells not following orders. They were curious. If the stem cells wouldn't turn into fat cells, then what did they become? Eventually, the … [Read more...] about Researchers Discover New Type of Stem Cell State
Doris Tyler lay on the examining table as the doctor stuck a long, thin tube into her belly. The doctor pulled back a plunger, and the syringe quickly filled with yellow blobs tinged with pink.“Look at that beautiful fat coming out. Liquid gold!” one of the clinic’s staff exclaimed in a video of the procedure provided to The Washington Post.Hidden in that fat were stem cells with the amazing power to heal, the Stem Cell Center of Georgia had told Tyler. The clinic is one of hundreds that have popped up across the country, many offering treatments for conditions from Parkinson’s disease to autism to multiple sclerosis.Federal regulators have not approved any of their treatments, and critics call such clinics modern-day snake-oil salesmen. But on that day in 2016, Tyler trusted the clinic to extract stem cells from her fat and inject them into her eyes, where she was told they could halt or even cure the macular degeneration threatening her sight.Five days after … [Read more...] about Miracle cures or modern quackery? Stem cell clinics multiply, with heartbreaking results for some patients.
SZEGED, Hungary, April 18 (Reuters) - Igor, a Siberian tiger in a Hungarian zoo, received stem-cell joint treatment on Wednesday which doctors hoped would help heal its hip and allow it to live happily, on less medicine.Igor is a 13-year old tiger living in the zoo in the southern Hungarian town of Szeged. It has been suffering from hip joint pains for years.The treatment, used more widely on humans than animals, cures injured joints with tissue taken from patients' own fatty tissue, which contains regenerative stem cells, doctors said. These are injected back into the ailing joints. 10 PHOTOS Siberian tiger gets stem-cell hip treatment in Hungary See Gallery Siberian tiger gets stem-cell hip treatment in Hungary Veterinarian, Robert Gippert (R) performs non invasive stem cell surgery on Igor, the 13 year-old Siberian tiger in Zoo Szeged, Hungary, April 18, 2018. REUTERS/Bernadett Szabo Igor, the 13 year-old Siberian tiger lies on the operation table before the … [Read more...] about Siberian tiger gets stem-cell hip treatment in Hungary