Osteoporosis affects about 400,000 people in Switzerland, mostly women after menopause. It is often described as a silent disease, because bone loss usually occurs little by little over the years and without any symptoms. The body gradually absorbs calcium from the bones, which become brittle. This process is controlled via what is called the parathyroid hormone (PTH) and a closely related peptide - a protein fragment. They bind to the PTH-1 receptor, thereby telling the body to either release calcium from the bone or to build new bone. An Extremely Difficult Undertaking Disadvantages of Current Treatment Understanding a Whole Class of Receptors … [Read more...] about From Receptor Structure to New Osteoporosis Drugs
New bone building drug
Home News Health Mind Daily news 23 October 2018 By Yvaine YeBusy feet, better memory. A hormone released by bone during exercise improves memory storage and retrieval in aged mice – and a new study into the way it operates has identified a protein that could form the basis of a treatment for age-related memory loss. As we get older, the gearwheels that keep our body functioning – such as hormone secretion and cell regeneration – turn at a slower rate. For instance, a bone-building hormone called osteocalcin is produced at a reduced level as … Popular Your brain is like 100 billion mini-computers all working together Hungry stomach hormone promotes growth of new brain cells Fasting power: Can going without food really make you healthier? Advertisement … [Read more...] about Bone hormone released during exercise may lead to new memory-loss drug
The Resomator stands monolithic in the corner of a room on the ground floor of a building at UCLA. It’s as sterile as a hospital in here, but every patient is already dead. This is the penultimate stage of their time under the care of Dean Fisher, director of the Donated Body Program at the UCLA David Geffen School of Medicine. After dissection, bodies are wheeled in under crisp sheets for disposal in Fisher’s alkaline hydrolysis machine, which turns them into liquid and pure white bone. Later, their air-dried bones will be pulverized and scattered off the coast by nearby Camp Pendleton, the Marine Corps base, where they will float and then disperse, because pure calcium phosphate dissolves very slowly. From a Coast Guard helicopter, it looks like drug lords flushing their stash. The machine is mid-cycle, emitting a low hum like a lawnmower several gardens away. It’s a rectangular box as big as a van, and its stainless steel panels neatly hide pipes, a panel of … [Read more...] about A New Way to Dispose of Corpses—With Chemistry!
I’ve been working to sprinkle in some non-science fiction and fantasy books into my to-read list lately. To that end, I picked up Brian Merchant’s The One Device: The Secret History of the iPhone, and I’ve been working my way through it whenever I have a couple of spare minutes. It’s a fascinating exploration into not only how the iPhone came to be, but also what goes into making each and every phone — and it’s not always a pretty picture. As usual, there’s a whole stack of science fiction and fantasy novels hitting bookstores this month, too. Here’s 15 novels coming out in March that caught our eyes. March 6th Children of Blood and Bone by Tomi Adeyemi The debut novel from Tomi Adeyemi, Children of Blood and Bone is the first in a trilogy. In the recent past, King Saran banished magic from the land of Orïsha, killed its magic wielders and rules with a tyrannical fist. Zélie Adebola lost her mother in the purge, but sees a … [Read more...] about 15 new science fiction and fantasy books to read this March
Purdue researchers are developing and commercializing a targeted drug combination that once injected into a patient could speed up and improve bone fracture healing, and significantly cut recovery costs. Novosteo Inc., a startup developing the technology, was co-founded by father and son team Philip Low, the Purdue Presidential Scholar for Drug Discovery and the Ralph C. Corley Distinguished Professor of Chemistry and Stewart Low, a postdoctoral staff member in Purdue’s Department of Chemistry. Stewart Low said bone fractures can pose several risks to patients. “People over 65 years of age who experience bone fractures, specifically hip fractures, have a one in four chance of dying from fracture-related complications. Half of these patients will not regain full mobility within a year,” he said. “We plan to focus initially on hip fractures in the elderly. We believe this is an area of underdevelopment and concern, so our goal is to help provide a better … [Read more...] about Targeted Drug Combo Could Expedite Bone Fracture Healing, be Used as Injection