A major factor underlying Parkinson's Disease (PD) pathology is the loss of dopamine neurons in the substantia nigra, and thus current therapies often aim to restore dopamine signaling. However, these treatments are not curative. The most promising approach for truly reversing disease progress involves the replacement of the specific dopamine neurons that have been lost, and this is the focus of a special issue on Parkinson's Disease, published in Stem Cells and Development, a peer-reviewed journal published by Mary Ann Liebert, Inc., publishers. The special issue is available free on the Stem Cells and Development website until August 24, 2018. In "Autologous Induced Pluripotent Stem Cell-Derived Neurons to Treat Parkinson's Disease ,"Jeanne F. Loring, PhD, the Scripps Research Institute (La Jolla, CA), discusses impending clinical trials involving stem cell-derived therapies for treating PD. Loring contends that individualized dopamine neurons … [Read more...] about A Promising Approach to Translational Research on Stem Cells for Parkinson’s Disease
Ethical stem cells
Doris Tyler lay on the examining table as the doctor stuck a long, thin tube into her belly. The doctor pulled back a plunger, and the syringe quickly filled with yellow blobs tinged with pink.“Look at that beautiful fat coming out. Liquid gold!” one of the clinic’s staff exclaimed in a video of the procedure provided to The Washington Post.Hidden in that fat were stem cells with the amazing power to heal, the Stem Cell Center of Georgia had told Tyler. The clinic is one of hundreds that have popped up across the country, many offering treatments for conditions from Parkinson’s disease to autism to multiple sclerosis.Federal regulators have not approved any of their treatments, and critics call such clinics modern-day snake-oil salesmen. But on that day in 2016, Tyler trusted the clinic to extract stem cells from her fat and inject them into her eyes, where she was told they could halt or even cure the macular degeneration threatening her sight.Five days after … [Read more...] about Miracle cures or modern quackery? Stem cell clinics multiply, with heartbreaking results for some patients.
ORLANDO, Fla.--(BUSINESS WIRE)--Apr 26, 2018--Hesperos, Inc. has increased its pioneering human-on-a-chip drug testing capabilities by adding a new in vitro, human-human neuromuscular model to its patented multi-organ microfluidic device systems. Abnormal function of the neuromuscular junction is associated with neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS) and spinal muscular atrophy, and a human model will be critical in developing and selecting effective drugs to treat these diseases.This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20180426006161/en/(Graphic: Business Wire)The breakthrough technology is described in a recent Biomaterials paper by Hesperos CSO James Hickman from the Hybrid Systems Laboratory at the University of Central Florida, “ Stem cell derived phenotypic human neuromuscular junction model for dose response evaluation of therapeutics.” The technology is licensed to … [Read more...] about Human-on-a-chip Company Hesperos Licenses First Functional Stem-Cell Derived Neuromuscular Junction Model
Donor age does not appear to influence the functionality of stem cells derived from adult body tissues, concludes a new review. The analysis of research on induced pluripotent stem cells (iPSCs) finds that not only are typical signs of aging reversed in iPSCs, but cells derived from both older and younger donors show the same ability to differentiate into mature body cells. This validates iPSCs as a viable alternative to embryonic stem cells in regenerative medicine. Published in Frontiers in Cardiovascular Medicine, the study highlights the enormous potential of iPSCs derived from elderly patients to treat their age-related diseases -- and indicates future areas of research for this relatively new field. "As average life expectancy continues to rise, so does the rate of age-related chronic and degenerative diseases," explains Dr. Nicolle Kränkel from Charité, a medical university in Germany. "Organ replacement and other cell-based treatments could increase … [Read more...] about Stem Cells From Adults Function Just as Well as Those From Embryos
DUBLIN--(BUSINESS WIRE)--Apr 24, 2018--The "Stem Cell Assay Market by Type (Viability, Purification, Identification), Cell Type (Mesenchymal, iPSCs, HSCs, hESCs), Product & Service (Instruments, Kits), Application (Regenerative Medicine, Clinical Research), End User - Global Forecast to 2023" report has been added to ResearchAndMarkets.com's offering.The stem cell assay market is expected to reach USD 1,978.7 million by 2023 from USD 791.9 million in 2018, at a CAGR of 20.1%The availability of funding for stem cell research; rising incidence of target indications; technological advancements in stem cell research instruments and the introduction of novel stem cell products; and the growth of end-use industries are the major factors driving the growth of this market. On the other hand, ethical issues related to embryonic stem cell research and the high cost of stem cell analysis instruments and reagents are factors expected to restrain the growth of this market to a certain … [Read more...] about Global Stem Cell Assay (Viability, Purification, Identification) Market, 2018-2023 by Cell Type, Product & Service, Application & End User