The fast-paced world we live in is a perfect driver of stress. The racing heart, knots in the stomach and vague sense of agitation are an unavoidable part of the human condition. But chronic stress can, over time, harm the body, causing everything from inflammation to cardiometabolic disease. In some cases, stress may play a role in cancer. But just how tightly are these two conditions linked? Studies suggest several ways that stress may influence cancer development, said Shelley Tworoger, an associate professor of population science at the Moffitt Cancer Center in Tampa, Florida. Tworoger spoke about these links during a talk earlier this month at the annual American Association for Cancer Research meeting in Atlanta. [7 Cancers You Can Ward Off With Exercise] In those who already have certain types of cancer, stress can accelerate progression and worsen outcomes, increasing evidence suggests. But "there's more question" about whether or not chronic stress can cause cancer in the … [Read more...] about Can Chronic Stress Cause or Worsen Cancer? Here’s What the Evidence Shows.
Chronic inflammation causes
Inflammation is a balanced physiological response -- the body needs it to eliminate invasive organisms and foreign irritants, but excessive inflammation can harm healthy cells, contributing to aging and chronic diseases. To help keep tabs on inflammation, immune cells employ a molecular machine called the NLRP3 inflammasome. NLRP3 is inactive in a healthy cell, but is switched "on" when the cell's mitochondria (energy-generating organelles) are damaged by stress or exposure to bacterial toxins. However, when the NLRP3 inflammasome gets stuck in the "on" position, it can contribute to a number of chronic inflammatory conditions, including gout, osteoarthritis, fatty liver disease and Alzheimer's and Parkinson's diseases. In a new mouse study, researchers at University of California San Diego School of Medicine discovered a unique approach that might help treat some chronic inflammatory diseases: force cells to eliminate damaged mitochondria before they activate the NLRP3 inflammasome. … [Read more...] about In Mice, Eliminating Damaged Mitochondria Alleviates Chronic Inflammatory Disease
Increases in chronic inflammation—not the passage of time—is the main reason why injured bones do not heal as well with age. This is the finding of a study in mice and humans published March 18 in the Proceedings of the National Academy of Sciences (PNAS). The results revolve around the known breakdown, due to wear and tear, of the protein machines and large molecules necessary for the life of human cells, the remnants of which trigger the immune system. First studied in its role in destroying invading microbes, this system also can react to the body's own proteins to cause inflammation, a response that fights infection at the site of injury and transitions into the healing process. The current study explains how this age-driven increase in immune signals diminishes the ability of stem cells—essential ingredients in bone repair—to multiply. This results in a smaller number of stem cells in the aged skeleton, say the study authors, and compromises their ability … [Read more...] about ‘Inflamm-aging’ Causes Loss of Bone Healing Ability in the Elderly
Targets Liver Cancer JENKINTOWN, Pa.–(BUSINESS WIRE)–March 19, 2019– SFA Therapeutics today announced approval of the second key U.S. patent derived from its research & development program, which utilizes microbiome-derived metabolite small molecules as drugs to modulate the body’s anti-inflammatory and immune systems (USPTO #10,231,941). As a result of this new patent, targeting Ffar2 (GPR43) and Ffar3 (GPR441) and down-regulation of NF-ĸB, the therapeutic applications of SFA’s first major drug, SFA001, will now expand from prevention of the progression of hepatitis B to hepatocellular carcinoma (HCC- the most prevalent form of liver cancer) to direct treatment for patients afflicted with liver fibrosis, NASH, or liver cancer derived from HCC. Commenting on the significance of this achievement, Dr. Mark Feitelson, Ph.D., Professor of Biology and Chair of the … [Read more...] about SFA Therapeutics Wins Second Key U.S. Patent For Treatment of Chronic Liver Diseases
Inflammation is a vital part of the immune system's response to injury and infection. It is the body's way of signaling the immune system to heal and repair damaged tissue, as well as defend itself against foreign invaders, such as viruses and bacteria. Without inflammation as a physiological response, wounds would fester, and infections could become deadly. However, if the inflammatory process goes on for too long or if the inflammatory response occurs in places where it is not needed, it can become problematic. Chronic inflammation has been linked to certain diseases such as heart disease or stroke, and may also lead to autoimmune disorders, such as rheumatoid arthritis and lupus. But a healthy diet and lifestyle can help keep inflammation under control. Acute inflammation Acute inflammation occurs after a cut on the knee, a sprained ankle or a sore throat. It's a short-term response with localized effects, meaning it works at the precise place where a … [Read more...] about What Is Inflammation?