It's a painful, chronic, and for some, untreatable condition. More than 700,000 Americans suffer from Crohn's disease, an inflammatory bowel disease that causes inflammation of the digestive tract that can lead to abdominal pain, severe diarrhea, fatigue, weight loss and malnutrition. Now, scientists in the UK have launched a new clinical study to test the use of a stem cell treatment for the inflammatory bowel disease. Moeed Majeed has struggled to control his Crohn's disease for the past eight years. "I remember suddenly getting a lot of pain in my abdominal area, having to go to the bathroom a lot more, which was very unusual, and I wasn't eating a lot because it made me feel sick," he told CBS News. The chronic pain and fatigue became so debilitating he had to drop out of college and move home. A new clinical trial at Queen Mary University of London is working to help people like Majeed whose symptoms aren't responsive to available drugs and surgery. "What we're doing is … [Read more...] about Crohn’s disease patients test experimental stem cell treatment
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[STK][IN] HEA MTC BIO[SU] TDS TRI-- WITH PHOTO -- TO BUSINESS, HEALTH, AND MEDICAL EDITORS:MaxCyte Reports Preclinical Results at ASGCT Annual Meeting ShowingEfficient Correction of Sickle Cell Mutation in Hematopoietic StemCells (HSC)GAITHERSBURG, Md., May 21, 2018 /PRNewswire/ -- MaxCyte, the globalcell-based medicines and life sciences company, today announced thatLinghong Li, PhD, Director, Cell Engineering, presented pre-clinicaldata at the annual meeting of the American Society of Gene and CellTherapy (ASGCT) in Chicago on Friday, May 18, 2018, in which MaxCyte'snon-viral cell engineering technology was used for CRISPR-mediatedgene-correction of a mutation within the hemoglobin gene of cells froma sickle cell disease (SCD) patient.SCD comprises a group of red blood cell disorders associated withmutations within the gene that encodes hemoglobin. Correction of thesemutations via gene editing offers potential for a new curativetreatment for individuals living with SCD. … [Read more...] about MaxCyte Reports Preclinical Results at ASGCT Annual Meeting Showing Efficient Correction of Sickle Cell Mutation in Hematopoietic Stem Cells (HSC)
On the first Saturday of March, Kristin Comella put on a white doctor’s coat and took the stage at the fourth annual conference for the Academy of Regenerative Practices. The founder and president of the academy, Comella also oversees an expanding empire of stem cell clinics that promise patients cures for most anything that ails them. None of those treatments—for everything from diabetes and asthma to multiple sclerosis and arthritis—have been approved by the US Food and Drug Administration. The procedure—which costs a few thousand dollars—is always pretty much the same, regardless of its purported target. It involves sucking out some of a patient’s fat tissue with a liposuction needle, isolating the stem cells within, and reinjecting them into the patient’s body. The simplicity of the procedure is why people like Comella say it’s “insane” for the FDA to try to regulate stem cells. So it was surprising when she announced … [Read more...] about Is This Stem Cell Clinic Really Making Cancer Vaccines?
Medical researchers in Barcelona. Photo: Josep Lago / AFP Doctors in Spain have announced the world's first clinical trial to cure five HIV patients within three years using transplants of blood from umbilical cords. Spain’s National Organization of Transplants (ONT) announced a plan that will be the world’s first of its kind to cure five people with HIV over the next three years, recreating the case of the only known person to be completely cured of the virus. Plans for the clinical trial were unveiled at a haematology conference in Valencia on Thursday. The project seeks to be the world’s first clinical trial of its kind by recreating the success of Timothy Ray Brown - the only living person ever to be completely cured of HIV, known as "the Berlin patient". The 157 donors selected by ONT together with national blood banks all have a genetic mutation which allows them to resist HIV. "This project can put us at the cutting edge of this field within … [Read more...] about Spain starts ambitious trial to cure HIV using umbilical cord stem cells
A US scientists examines stem cells File Photo: Spencer Platt/Getty Images North America/AFP Scientists at Spain's National Cancer Research Centre (CNIO) said on Wednesday they had made mature cells in living mice revert to their youthful, versatile state, in a step towards the goal of tissue regeneration by stem cells. Right now, the technique is at its earliest stage and is hedged with safety questions, which makes it impossible to envisage in humans. But, said the researchers, it opens up a new strategy leading to a beguiling end: that one day damaged tissue will be healed by simply reprogramming nearby adult cells into replacements for the lost or diseased area. A transplant would not be needed. Stem cells have excited huge interest in medical research. They are immature cells that differentiate into the specialized cells that comprise and maintain the human body. In 2006, a team led by Shinya Yamanaka in Japan announced a breakthrough. A clutch of four genes … [Read more...] about Spanish scientists make stem cell breakthrough