A London man appears to be free of the AIDS virus after a stem cell transplant, the second success including the "Berlin patient," doctors reported. The therapy had an early success with Timothy Ray Brown, a U.S. man treated in Germany who is 12 years post-transplant and still free of HIV. Until now, Brown is the only person thought to have been cured of infection with HIV, the virus that causes AIDS. Such transplants are dangerous and have failed in other patients. They're also impractical to try to cure the millions already infected.The latest case "shows the cure of Timothy Brown was not a fluke and can be recreated," said Dr. Keith Jerome of Fred Hutchinson Cancer Research Center in Seattle who had no role. He added that it could lead to a simpler approach that could be used more widely.The case was published online Monday by the journal Nature and will be presented at an HIV conference in Seattle.The patient has not been identified. He was diagnosed with HIV in 2003 and started … [Read more...] about 2nd man apparently free of AIDS virus following stem cell transplant
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For a decade, Roy Palmer had no control of his legs. The man from Gloucester, England, had multiple sclerosis, or MS, which results in the body's immune system eating away at the protective covering of nerves, disrupting communication between the brain and the body. Palmer had no feeling in his legs and used a wheelchair. But last year, he received a life-changing treatment that restored his ability to walk -- and dance -- again, the BBC reports. The dad first heard of the treatment, called HSCT (hematopoietic stem cell transplantation), on the BBC program, "Panorama." "Two people on that program went into Sheffield Hospital in wheelchairs and they both came out walking," Palmer said. "As soon as we saw that, we both cried," Palmer's wife told the BBC. According to the National MS Society, HSCT still considered experimental, but Palmer decided it was worth a try. "If they can have that done, on a trial, why can't I have it done?" Palmer said. So last year, the … [Read more...] about After stem cell transplant, man with MS able to walk and dance for first time in 10 years
[STK][IN] HEA MTC BIO[SU] TDS TRI-- WITH PHOTO -- TO BUSINESS, HEALTH, AND MEDICAL EDITORS:MaxCyte Reports Preclinical Results at ASGCT Annual Meeting ShowingEfficient Correction of Sickle Cell Mutation in Hematopoietic StemCells (HSC)GAITHERSBURG, Md., May 21, 2018 /PRNewswire/ -- MaxCyte, the globalcell-based medicines and life sciences company, today announced thatLinghong Li, PhD, Director, Cell Engineering, presented pre-clinicaldata at the annual meeting of the American Society of Gene and CellTherapy (ASGCT) in Chicago on Friday, May 18, 2018, in which MaxCyte'snon-viral cell engineering technology was used for CRISPR-mediatedgene-correction of a mutation within the hemoglobin gene of cells froma sickle cell disease (SCD) patient.SCD comprises a group of red blood cell disorders associated withmutations within the gene that encodes hemoglobin. Correction of thesemutations via gene editing offers potential for a new curativetreatment for individuals living with SCD. … [Read more...] about MaxCyte Reports Preclinical Results at ASGCT Annual Meeting Showing Efficient Correction of Sickle Cell Mutation in Hematopoietic Stem Cells (HSC)
On the first Saturday of March, Kristin Comella put on a white doctor’s coat and took the stage at the fourth annual conference for the Academy of Regenerative Practices. The founder and president of the academy, Comella also oversees an expanding empire of stem cell clinics that promise patients cures for most anything that ails them. None of those treatments—for everything from diabetes and asthma to multiple sclerosis and arthritis—have been approved by the US Food and Drug Administration. The procedure—which costs a few thousand dollars—is always pretty much the same, regardless of its purported target. It involves sucking out some of a patient’s fat tissue with a liposuction needle, isolating the stem cells within, and reinjecting them into the patient’s body. The simplicity of the procedure is why people like Comella say it’s “insane” for the FDA to try to regulate stem cells. So it was surprising when she announced … [Read more...] about Is This Stem Cell Clinic Really Making Cancer Vaccines?
Medical researchers in Barcelona. Photo: Josep Lago / AFP Doctors in Spain have announced the world's first clinical trial to cure five HIV patients within three years using transplants of blood from umbilical cords. Spain’s National Organization of Transplants (ONT) announced a plan that will be the world’s first of its kind to cure five people with HIV over the next three years, recreating the case of the only known person to be completely cured of the virus. Plans for the clinical trial were unveiled at a haematology conference in Valencia on Thursday. The project seeks to be the world’s first clinical trial of its kind by recreating the success of Timothy Ray Brown - the only living person ever to be completely cured of HIV, known as "the Berlin patient". The 157 donors selected by ONT together with national blood banks all have a genetic mutation which allows them to resist HIV. "This project can put us at the cutting edge of this field within … [Read more...] about Spain starts ambitious trial to cure HIV using umbilical cord stem cells